Xihan Zhang et al.’s new paper out now in Nature Neuroscience: “The cell-type underpinnings of the human functional cortical connectome”
Read here: https://www.nature.com/articles/s41593-024-01812-2
Xihan links functional macroscale organization in the human brain (connectivity networks and gradients) with biological microscale organization (cell-type distribution). Her work reveals that functional organization of human cortex is reflected in the spatial variability of different cell types. She examines associations between the spatial abundance of cell-types with functional gradients and networks across the cortical sheet.
She shows functional networks have unique cell-type distribution fingerprints, and ML models can predict FC-network affiliation of post-mortem cortical tissue through these fingerprints alone.
