September 20, 2023
Sid Chopra, post-doc at the Holmes Lab, has a new paper out now in JAMA Psychiatry! This paper analyzes network-based spreading of grey matter changes across multiple stages of psychosis.
Check it out here: www.doi.org/10.1001/jamapsychiatry.2023.3293
In this case-control study of 534 participants from 4 independent samples spanning different stages of psychotic illness, it was found that gray matter alterations were constrained by the underlying architecture of the brain’s axonal pathways, and the hippocampus was consistently identified as a putative source from which volume loss may spread to connected regions.
The paper was co-authored by Holmes lab post-doc Ashlea Segal, and post-doc Winnie Orchard also worked on the paper. Congrats, Sid, Ashlea and Winnie!
