Latest Lab News

Sid Chopra et al.’s new paper is out now in Science Advances: “Generalizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness”

New paper out now in Science Advances:
“Generalizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness”
By Sidhant Chopra and Holmes Lab

Read it here: https://www.science.org/doi/10.1126/sciadv.adn1862

This paper demonstrates using ‘meta-matching’ technique to build reliable, generalizable and interpretable models of cognitive functioning without 1000s of subjects/patients.

The key takeaway is You don’t need your own big data to make robust & generalizable brain-based behavioural predictions, especially for cognition. Methods like meta-matching (https://nature.com/articles/s41593-022-01059-9) are effective across diverse small clinical samples.

Holmes lab paper on brain-protective impacts of parenthood covered by New York Post, Rutgers Health, Science Daily and more!

Some great coverage of Winnie Orchard’s new Holmes Lab paper, recently published in PNAS! New York Post: https://nypost.com/2025/02/28/health/having-kids-can-fight-brain-aging-the-more-children-the-better/?utm_campaign=nypost&utm_medium=referral 
 Rutgers News www.rutgers.edu/news/how-par… Science Daily https://www.sciencedaily.com/releases/2025/02/250226141927.htm

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